Grote Hall 411
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The Department of Chemistry and Physics kicks off its fall semester seminar series with a talk presented by Professor Kevin L. Bicker from Middle Tennessee State University.

Using the Peptoid Library Agar Diffusion assay to discover antimicrobial peptoids

Kevin L. Bicker, Ph.D.

Middle Tennessee State University

Professor of Chemistry

Associate Dean for Research, College of Basic and Applied Sciences

Rapid emergence of antimicrobial resistant organisms necessitates equally rapid methods for the development of new antimicrobial compounds.  While peptoids have proven themselves to be promising anti-infective agents against bacteria, fungi, and viruses, there is a clear need for accelerated discovery platforms.  Our group has developed and implemented a high-throughput method to screen combinatorial libraries of peptoids immobilized on beads embedded into solid growth media.  Termed the Peptoid Library Agar Diffusion (PLAD) assay, this technique allows for the rapid interrogation of diverse peptoid libraries against a variety of bacterial and fungal pathogens, including those grown in biofilm.  Our use of this assay to discover promising lead peptoids against microbes such as Candida albicans, Cryptococcus neoformans, Staphylococcus aureus, and Pseudomonas aeruginosa, as well as subsequent development of these compounds as antimicrobial agents will be discussed.

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